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![]() ![]() Top AWS Architect Interview Questions For 2. Why AWS Architect Interview Questions ? For the 6th straight year, Gartner placed Amazon Web Services in the “Leaders” quadrant. Also Forbes reported, AWS Certified Solutions Architect Leads the 1. Top Paying IT Certifications. Undoubtedly, AWS Solution Architect position is one of the most sought after amongst IT jobs. We at Edureka are committed to helping you upgrade your career in sync with industry requirements. That’s why we have created a list of AWS Architect Interview questions and answers that will most probably get asked during your interview. If you’ve attended an AWS Architect interview or have additional questions beyond what we have covered, we encourage you to add them in the comments section below. In the meantime, you can maximize the Cloud computing career opportunities that are sure to come your way by taking AWS Architect online training with Edureka. You can write the AWS Architect certification exam after the course at edureka. Get AWS Certified! The AWS Solution Architect Role: With regards to AWS, a Solution Architect would design and define AWS architecture for existing systems, migrating them to cloud architectures as well as developing technical road- maps for future AWS cloud implementations. ![]() 3 thoughts on “ Tutorial – How to setup a KMS server for a Windows Domain ” Peter July 26, 2014 at 8:07 am. Very nicely done! Clear and concise. So, in this AWS Architect interview questions blog, in every section, we will start with the basics, and then move our way forward to more technical questions, for the best learning experience please refer the questions in sequence so that the concepts for the next question will be clear in the first. Before moving ahead, you may go through the recording of AWS Interview Questions And Answers where our instructor has shared his experience and expertise that will help you to crack any AWS Solutions Architect Interview: AWS Interview Questions And Answers | AWS Tutorial | AWS Training | Edureka. Section 1: What is Cloud Computing. For a detailed discussion on this topic, please refer our Cloud Computing blog. I have some private servers on my premises, also I have distributed some of my workload on the public cloud, what is this architecture called? Virtual Private Network. Private Cloud. Virtual Private Cloud. Hybrid Cloud. Answer D. Explanation: This type of architecture would be a hybrid cloud. Why? Because we are using both, the public cloud, and your on premises servers i.To make this hybrid architecture easy to use, wouldn’t it be better if your private and public cloud were all on the same network(virtually). more. This is established by including your public cloud servers in a virtual private cloud, and connecting this virtual cloud with your on premise servers using a VPN(Virtual Private Network). Section 2: Amazon EC2. For a detailed discussion on this topic, please refer our EC2 AWS blog. What does the following command do with respect to the Amazon EC2 security groups? Create. Security. Group. Groups the user created security groups into a new group for easy access. Creates a new security group for use with your account.Creates a new group inside the security group.Creates a new rule inside the security group.Answer B. Explanation: A Security group is just like a firewall, it controls the traffic in and out of your instance. there. In AWS terms, the inbound and outbound traffic.The command mentioned is pretty straight forward, it says create security group, and does the same. Moving along, once your security group is created, you can add different rules in it. For example, you have an RDS instance, to access it, you have to add the public IP address of the machine from which you want access the instance in its security group. You have a video trans- coding application. The videos are processed according to a queue. If the processing of a video is interrupted in one instance, it is resumed in another instance. Currently there is a huge back- log of videos which needs to be processed, for this you need to add more instances, but you need these instances only until your backlog is reduced. Which of these would be an efficient way to do it? You should be using an On Demand instance for the same. Why? First of all, the workload has to be processed now, meaning it is urgent, secondly you don’t need them once your backlog is cleared, therefore Reserved Instance is out of the picture, and since the work is urgent, you cannot stop the work on your instance just because the spot price spiked, therefore Spot Instances shall also not be used. Hence On- Demand instances shall be the right choice in this case. You have a distributed application that periodically processes large volumes of data across multiple Amazon EC2 Instances. The application is designed to recover gracefully from Amazon EC2 instance failures. You are required to accomplish this task in the most cost effective way. Which of the following will meet your requirements? Spot Instances. Reserved instances. Dedicated instances. On- Demand instances. Answer: AExplanation: Since the work we are addressing here is not continuous, a reserved instance shall be idle at times, same goes with On Demand instances. Also it does not make sense to launch an On Demand instance whenever work comes up, since it is expensive. Hence Spot Instances will be the right fit because of their low rates and no long term commitments. How is stopping and terminating an instance different from each other? Starting, stopping and terminating are the three states in an EC2 instance, let’s discuss them in detail: Stopping and Starting an instance: When an instance is stopped, the instance performs a normal shutdown and then transitions to a stopped state. All of its Amazon EBS volumes remain attached, and you can start the instance again at a later time. You are not charged for additional instance hours while the instance is in a stopped state. Terminating an instance: When an instance is terminated, the instance performs a normal shutdown, then the attached Amazon EBS volumes are deleted unless the volume’s delete. On. Termination attribute is set to false. The instance itself is also deleted, and you can’t start the instance again at a later time. If I want my instance to run on a single- tenant hardware, which value do I have to set the instance’s tenancy attribute to? Dedicated. Isolated. One. Reserved. Answer A. Explanation: The Instance tenancy attribute should be set to Dedicated Instance. The rest of the values are invalid. When will you incur costs with an Elastic IP address (EIP)? When an EIP is allocated. When it is allocated and associated with a running instance. When it is allocated and associated with a stopped instance. Costs are incurred regardless of whether the EIP is associated with a running instance. Answer C. Explanation: You are not charged, if only one Elastic IP address is attached with your running instance. But you do get charged in the following conditions: When you use more than one Elastic IPs with your instance. When your Elastic IP is attached to a stopped instance. When your Elastic IP is not attached to any instance. How is a Spot instance different from an On- Demand instance or Reserved Instance? First of all, let’s understand that Spot Instance, On- Demand instance and Reserved Instances are all models for pricing. Moving along, spot instances provide the ability for customers to purchase compute capacity with no upfront commitment, at hourly rates usually lower than the On- Demand rate in each region. Spot instances are just like bidding, the bidding price is called Spot Price. The Spot Price fluctuates based on supply and demand for instances, but customers will never pay more than the maximum price they have specified. If the Spot Price moves higher than a customer’s maximum price, the customer’s EC2 instance will be shut down automatically. But the reverse is not true, if the Spot prices come down again, your EC2 instance will not be launched automatically, one has to do that manually. In Spot and On demand instance, there is no commitment for the duration from the user side, however in reserved instances one has to stick to the time period that he has chosen. Are the Reserved Instances available for Multi- AZ Deployments? Multi- AZ Deployments are only available for Cluster Compute instances types. Available for all instance types. Only available for M3 instance types. D. Not Available for Reserved Instances. Answer B. Explanation: Reserved Instances is a pricing model, which is available for all instance types in EC2. How to use the processor state control feature available on the c. Product comparison. Unlike traditional backup tools designed to work with physical machines, our product can operate at the virtualization layer, employing MS VSS (Volume Shadow Copy Service) to agentlessly backup/restore any guest machine of Hyper- V. Thus our solution doesn’t need an agent on a target virtual machine to create its point- in- time copy including its configuration, operating system, apps, etc. The current version can only protect entire virtual machines (online or offline) registered on a local Hyper- V host, where our product is deployed. 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Das Restless- Legs- Syndrom (RLS), englisch für Syndrom der ruhelosen Beine, auch Wittmaack- Ekbom- Syndrom oder Willis- Ekbom disease, ist gekennzeichnet durch in Ruhe und nachts verstärkte und tags sowie während Bewegung verringerte Missempfindungen sowie einen Bewegungsdrang in den Beinen, Füßen und weniger häufig auch in den Armen, oftmals einhergehend mit unwillkürlichen Bewegungen. Es wird zu den extrapyramidalen Hyperkinesien gerechnet. Im Deutschen spricht man von unruhigen Beinen, doch setzt sich auch umgangssprachlich zunehmend die Abkürzung RLS – manchmal aufgelöst zu „Rastloser Schlaf“ – als Krankheitsname durch. Das Syndrom gehört nach dem Klassifikationssystem für Schlafstörungen „International Classification of Sleep Disorders“ (ICSD- 2) zu den schlafbezogenen Bewegungsstörungen.[1] Die Störungen sind individuell unterschiedlich stark bis hin zur neurologischen Erkrankung. In der 2. Hälfte des 1. Jahrhunderts wurden die Krankheitszeichen von Thomas Willis zum ersten Mal beschrieben. Kliniker Theodor Wittmaack die Erkrankung nach ihrem auffälligsten Symptom, den unruhigen Beinen, als Anxietas tibiarum. Die Bezeichnung Restless Legs wurde 1. Stockholmer Neurologen Karl- Axel Ekbom geprägt.[2]Symptome. RLS- Patienten. Schlafstörungen(alle Formen)9. Bewegungsdrang(Ruhesituation)9. Neupro Rotigotine Transdermal Patch 2012 Presidential ElectionEmpfindungsstörung(Ruhesituation)9. Beschwerden(am Tag)7. Bewegung(Ruhesituation)5. Häufigkeit der Symptome bei Patienten mitidiopathischem RLS (nach Trenkwalder 1. Das RLS verursacht in Zuständen der Ruhe bzw. Entspannung in den Beinen und/oder Füßen (seltener auch in den Armen und/oder Händen) ein Ziehen, Spannen, Kribbeln, Schmerzen, Wärmegefühl oder andere als unangenehm empfundene Gefühle. Diese Missempfindungen führen bei den Betroffenen zum unwiderstehlichen Drang, sich zu bewegen, die Muskeln anzuspannen oder zu dehnen. At UCB our sense of purpose is. to help people suffering from severe neurological or immunological disorders lead normal, everyday lives. Our ambition is to deliver. Medications I've tried for CFS/ME. Since you're here, you might be interested in my CFS/ME/fibromyalgia treatment book. Note: because this list was growing extremely. Die Beschwerden sind abends oder nachts schlimmer als während des Tages, oder sie treten ausschließlich am Abend oder in der Nacht bei ruhigem Sitzen oder Liegen auf. Charakteristisch für das RLS ist die sofortige Linderung durch Muskeltätigkeit, d. h. Bewegen der betroffenen Gliedmaßen durch Umhergehen, Kniebeugen, Radfahren, periodisches Anspannen usw. Die Symptome kehren jedoch nach einer nur kurzfristigen Besserung für gewöhnlich bereits in der nächsten Ruhesituation unmittelbar wieder zurück. Die Häufung der Beschwerden abends und nachts (bei vielen Betroffenen grob im Zeitraum zwischen 2. Uhr) wird zirkadianen Rhythmen zugeschrieben. Sie geht also wohl nicht allein auf die zu dieser Tageszeit typische körperliche Ruhe zurück. Andererseits können Entspannungssituationen, Langeweile und eingeschränkte Bewegungsmöglichkeiten die Symptome unabhängig von der Tageszeit verstärken. Häufige Begleiterscheinungen des RLS sind periodische Zuckungen der Beine oder Arme im Schlaf (Periodic Limb Movements), ohne dass diese dem Patienten bewusst sind. Seltener können diese Bewegungen auch im wachen Zustand auftreten. Diese Zuckungen führen oftmals zu unbemerkten Störungen des Schlafes durch wiederholtes kurzes Aufwachen (sogenannte arousals). Idealtypisches“, gestörtes Schlafmuster eines RLS- Patienten (rot), das durch ständige arousals geprägt ist. Im Vergleich dazu die Schlafstadien eines Gesunden (blau). Die quälende Unruhe in den Gliedmaßen und der nicht zu unterdrückende Zwang, sich (z. B. Umherlaufen) zu bewegen, hindert die Betroffenen oftmals sehr wirksam daran, ein- und durchzuschlafen. Dabei muss sich der Patient – besonders bei sonst nur leicht ausgeprägten Symptomen – der eigentlichen Ursache für sein Problem nicht bewusst sein. Das Ausmaß an Schlafmangel durch die Störungen des Schlafs kann bei RLS- Patienten außergewöhnlich groß sein. In der Folge kommt es oft zu chronischer Müdigkeit am Tage, Antriebslosigkeit, Erschöpfung, Konzentrationsstörungen, Unruhe, Vergesslichkeit und einer Verschiebung des Tag- und- Nacht- Rhythmus. Als häufige Spätfolgen sind bei unbehandeltem Fortbestehen daher allgemeiner Leistungsabfall, soziale Isolation und – als schwerwiegendste Konsequenz – Depressionen[3] zu beobachten. Bei schmerzhaften Ausprägungen kann sich, wie bei allen andauernden Schmerzzuständen, auch ein chronisches Schmerzsyndrom ausbilden. ![]() Betroffene berichten bisweilen auch von weiteren Symptomen, die entweder mit dem gestörten Dopaminstoffwechsel oder den Folgen des Schlafmangels in Zusammenhang stehen könnten. Beispiele wären etwa nächtlicher Heißhunger, Unverträglichkeit von Alkohol und Koffein, chronische Magen- Darm- Beschwerden, Spannungskopfschmerzen und Verschlimmerung des RLS nach sportlichen Anstrengungen oder durch Wärme bzw. Kälte. Die Diagnose wird oft erst von einem Nervenarzt (Neurologe oder Psychiater) gestellt. Bei der Diagnostik steht die klinische Symptomatik im Vordergrund. Als Werkzeug steht eine validierte Skala zur Feststellung der Schwere des Krankheitsbildes zur Verfügung (RLS Severity Scale). Bereits eine einmalige Gabe von L- Dopa bzw. Apomorphin bessert die Symptome bei fast allen RLS- Patienten dramatisch, so dass ein erfolgreich durchgeführter Versuch als beweisender Test dienen kann (ex juvantibus). Ein sogenannter Immobilisationtest, bei dem die Beine des Betroffenen für eine Zeit lang fixiert werden, kann die genannten begleitenden unwillkürlichen, d. h. Zuckungen der Muskeln zu Tage treten lassen. In unklaren Fällen ist eine Polysomnographie im Schlaflabor erforderlich. Differentialdiagnostisch muss das RLS gegen Polyneuropathie, Funikuläre Myelose (Vitamin- B1. Mangel), Radikulopathie, Akathisie, Venenleiden, Wadenkrämpfe (Crampi nocturni), arterielle Verschlusskrankheit („Schaufensterkrankheit“), Pruritus und Einschlafmyoklonien abgegrenzt werden. . Die Begleiterscheinungen des RLS führen sehr häufig zu einer falschen Diagnose, da die zugrundeliegende Krankheit oftmals nicht gesehen wird.Die ärztliche Annahme, es läge ursächlich eine psychosomatische Störung, eine Depression oder Hypochondrie vor, führt im Extremfall zu dann aber typischerweise langjährigen, durch häufige Arztwechsel geprägte „Patientenkarrieren“, in denen Suizidversuche oder überflüssige Aufenthalte in der Psychiatrie vorkommen können.Es wird geschätzt, dass je nach Schweregrad etwa 5–1.Bevölkerung in Deutschland vom RLS betroffen sind.[4] Es ist damit eine der häufigsten neurologischen Erkrankungen überhaupt.Patienten sind Frauen.Allerdings sind die Symptome bei ca. Betroffenen nur sehr schwach ausgeprägt, so dass eine medikamentöse Therapie bei ihnen nicht notwendig ist. In den USA wird der Anteil der behandlungsbedürftigen Bevölkerung auf 2,7 % geschätzt.[5]Die Erfahrungen in den Schlaflaboren zeigen, dass bis zu 2. Schlafstörungen durch unerkannte Formen des RLS verursacht werden. Die Veranlagung zu dieser Krankheit kann autosomal- dominant vererbt werden. Die familiäre Prädisposition ist inzwischen auch durch Zwillingsstudien bestätigt worden, der Grad des genetischen Einflusses bleibt aber ungewiss.[6] Zur Lokalisation des verursachenden Gens wird geforscht.[7][8] Wird das RLS in einer Familie weitergegeben, so beobachtet man die Tendenz, dass die Symptome mit jeder nachfolgenden Generation früher auftreten und stärker ausgeprägt sind (Antizipation).[9]Man unterscheidet zwischen einer sekundären (symptomatischen) und einer idiopathischen Form des RLS. Die sekundäre Form des RLS kann durch Krankheiten bzw. Zustände wie Eisenmangelanämie[1. Anämie, Urämie, Niereninsuffizienz mit Dialyse[1. Arthritis, Morbus Parkinson u. a. Erkrankungen sowie durch eine Reihe von Medikamenten (vor allem Dopaminantagonisten und diverse Antidepressiva)[1. ![]() Außerdem kann eine Schwangerschaft eine Rolle spielen. Nach schweren operativen Eingriffen wie etwa einer Total- Endoprothese des Knies kommt es häufig zur Verschlimmerung oder zum ersten Auftreten eines RLS.[1. Die sekundäre Form verschwindet für gewöhnlich, wenn ihre Ursache beseitigt wurde, doch kann sie bei gegebener Veranlagung auch der Auslöser für die Manifestation der idiopathischen Form sein. Die selbständige (idiopathische) Ausprägung der Krankheit ist als genetische Prädisposition erbbar.[1. Häufig beginnt sie im dritten Lebensjahrzehnt.[1. Es gibt Hinweise darauf, dass oftmals sekundäre Formen des RLS sowie einige weitere Krankheiten (z. B. Hypothyreose) Auslöser der idiopathischen Form sein könnten. Neupro Rotigotine Transdermal Patch 2012 FordIn leichteren Fällen oder in der Anfangsphase der Erkrankung können Form, Häufigkeit und Stärke der Beschwerden individuell erheblich variieren. Neupro Patch - FDA prescribing information, side effects and uses. Parkinson's Disease (PD)NEUPRO is indicated for the treatment of Parkinson's disease. Restless Legs Syndrome (RLS)NEUPRO is indicated for the treatment of moderate- to- severe primary Restless Legs Syndrome. Neupro Patch Dosage and Administration. Dosage in Parkinson's Disease. Early- Stage Parkinson's Disease. In patients with early- stage Parkinson's disease, the recommended starting dose for NEUPRO is 2 mg/2. Based upon individual patient clinical response and tolerability, NEUPRO dosage may be increased weekly by 2 mg/2. The lowest effective dose is 4 mg/2. The maximum recommended dose for early- stage Parkinson's disease is 6 mg/2. Advanced- Stage Parkinson's Disease. In patients with advanced- stage Parkinson's disease, the recommended starting dose for NEUPRO is 4 mg/2. Based upon individual patient clinical response and tolerability, NEUPRO dosage may be increased weekly by 2 mg/2. The maximum recommended dose for advanced- stage Parkinson's disease is 8 mg/2. Dosage in Restless Legs Syndrome. In patients with Restless Legs Syndrome, the recommended starting dose for NEUPRO is 1 mg/2. Based upon individual patient clinical response and tolerability, NEUPRO dosage may be increased weekly by 1 mg/2.The lowest effective dose is 1 mg/2. on this page. The maximum recommended dose is 3 mg/2.Administration Information. NEUPRO is applied once a day. The adhesive side of the transdermal system should be applied to clean, dry, intact healthy skin on the front of the abdomen, thigh, hip, flank, shoulder, or upper arm. The transdermal system should be applied at approximately the same time every day, at a convenient time for the patient. Because NEUPRO is administered transdermally, food is not expected to affect absorption and it can be applied irrespective of the timing of meals. The application site for NEUPRO should be moved on a daily basis (for example, from the right side to the left side and from the upper body to the lower body). NEUPRO should not be applied to the same application site more than once every 1. If it is necessary to apply NEUPRO to a hairy area, the area should be shaved at least 3 days prior to NEUPRO application. The system should be applied immediately after opening the pouch and removing the protective liner. The system should be pressed firmly in place for 3. If the patient forgets to replace NEUPRO, or if the transdermal system becomes dislodged, another transdermal system should be applied for the remainder of the day. The prescribed dose may be achieved using single or multiple patches [see Patient Counseling Information (1. Discontinuation of NEUPROFor discontinuation of NEUPRO in patients with Parkinson's disease, reduce the daily dose by a maximum of 2 mg every 2. NEUPRO is achieved. For discontinuation of NEUPRO in patients with Restless Legs Syndrome, reduce the daily dose by 1 mg every 2. NEUPRO is achieved. Dosage Forms and Strengths. Transdermal System: 1 mg/2. Contraindications. NEUPRO is contraindicated in patients who have demonstrated hypersensitivity to rotigotine or the components of the transdermal system. Warnings and Precautions. Sulfite Sensitivity. NEUPRO contains sodium metabisulfite, a sulfite that may cause allergic- type reactions including anaphylactic symptoms and life- threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Falling Asleep During Activities of Daily Living and Somnolence. Patients with early- and advanced- stage Parkinson's disease and with Restless Legs Syndrome treated with NEUPRO have reported falling asleep while engaged in activities of daily living, including the operation of motor vehicles, which sometimes resulted in accidents. Although many of these patients reported somnolence while on NEUPRO, some did not perceive warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event. Some of these events have been reported as late as one year after initiation of treatment. In clinical trials in patients with Restless Legs Syndrome, 2% of patients treated with the maximum recommended NEUPRO dose (3 mg/2. It has been reported that falling asleep while engaged in activities of daily living always occurs in a setting of pre- existing somnolence, although patients may not give such a history. For this reason, prescribers should reassess patients for drowsiness or sleepiness especially since some of the events occur well after the start of treatment. Somnolence is a common occurrence in patients receiving NEUPRO. In patients taking the maximum recommended NEUPRO dose, there was an increased risk of somnolence for early- stage Parkinson's disease (NEUPRO 1. Parkinson's disease (NEUPRO 3. Restless Legs Syndrome (NEUPRO 1. Prescribers should also be aware that patients may not acknowledge drowsiness or sleepiness until directly questioned about drowsiness or sleepiness during specific activities. Patients should be advised to exercise caution while driving, operating machines, or working at heights during treatment with NEUPRO. Patients who have already experienced somnolence and/or an episode of sudden sleep onset should not participate in these activities while taking NEUPRO. Before initiating treatment with NEUPRO, patients should be advised of the potential to develop drowsiness and specifically asked about factors that may increase this risk with NEUPRO such as concomitant sedating medications and the presence of sleep disorders. If a patient develops daytime sleepiness or episodes of falling asleep during activities that require active participation (e. NEUPRO should ordinarily be discontinued [see Dosage and Administration (2. If a decision is made to continue NEUPRO, patients should be advised not to drive and to avoid other potentially dangerous activities. There is insufficient information to establish whether dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living. Hallucinations/Psychosis. There was an increased risk for hallucinations in patients with advanced- stage Parkinson's disease treated with NEUPRO. In patients taking the maximum recommended NEUPRO dose, the incidence of hallucinations was 7% for NEUPRO and 3% for placebo, and this treatment difference increased with increasing dose. Hallucinations were of sufficient severity to cause discontinuation of treatment (mainly during the dose escalation/titration period) in 3% of advanced- stage Parkinson's disease patients treated with the maximum recommended dose of NEUPRO compared with 1% of placebo- treated patients. Hallucinations have also been reported in post- marketing reports. Post- marketing reports indicate that patients may experience new or worsening mental status and behavioral changes, which may be severe, including psychotic behavior during NEUPRO treatment or after starting or increasing the dose of NEUPRO. Other drugs prescribed to improve the symptoms of Parkinson's disease can have similar effects on thinking and behavior. This abnormal thinking and behavior may consist of one or more of the following: paranoid ideation, delusions, hallucinations, confusion, disorientation, aggressive behavior, agitation, and delirium. These various manifestations of psychotic behavior were also observed during the clinical development of NEUPRO for early- and advanced- stage Parkinson's disease and Restless Legs Syndrome. Patients with a major psychotic disorder should ordinarily not be treated with NEUPRO because of the risk of exacerbating psychosis. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of NEUPRO [see Drug Interactions (7. Symptomatic Hypotension. Dopaminergic agonists, in clinical studies and clinical experience, appear to impair the systemic regulation of blood pressure, resulting in postural/orthostatic hypotension, especially during dose escalation. Parkinson's disease patients, in addition, appear to have an impaired capacity to respond to a postural challenge. For these reasons, both Parkinson's and Restless Legs Syndrome patients being treated with dopaminergic agonists ordinarily (1) require careful monitoring for signs and symptoms of postural hypotension, especially during dose escalation, and (2) should be informed of this risk. |
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November 2017
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